Research Paper Volume 10, Issue 7 pp 1597—1608

Aging exacerbates mortality of Acinetobacter baumannii pneumonia and reduces the efficacies of antibiotics and vaccine

Figure 7. Efficacy of imipenem/cilstatin treatment on respiratory A.baumannii infection. Young and aged mice were challenged intratracheally with 1.5×107 CFU of LAC-4. At 3 hpi, groups of five mice were i.p. injected with imipenem/cilstatin (20mg/20mg)/kg/day or saline twice a day. (A) Clinical score and (B) survival rate of mice were monitored for 7 days. Clinical score is expressed as means ± SEM. The data represent one of 2 independent experiments. Survival curves were compared using log-rank test. Statistical significance of clinical score was determined by Student’s t test. *, P < 0.05, **, P < 0.01 antibiotic-treated aged mice versus antibiotic-treated young mice.