Research Paper Volume 10, Issue 7 pp 1609—1626

Signatures of photo-aging and intrinsic aging in skin were revealed by transcriptome network analysis

Figure 4. The gene expression alterations that are specific to lower leg. (A) Pathway enrichment analysis of purple and magenta modules. Top 15 the most enriched pathways were used. (B) Heatmap displays the gene expression changes with aging involved in lipid metabolism (top), water loss regulation via skin (middle), and vasculature development (bottom) in lower leg.