Research Paper Volume 10, Issue 7 pp 1627—1639

A three-long non-coding RNA-expression-based risk score system can better predict both overall and recurrence-free survival in patients with small hepatocellular carcinoma

Figure 4. Gene enrichment analysis of the lncRNA-signature. (A) Gene set enrichment analysis in high-risk patients. Pathway PYK2 was significantly enriched in GEO (A) and TCGA (B) database simultaneously. (B) The bar chart of the significantly enriched pathways of the co-expressed genes of LINC00667 and NSUN5P2 (P<0.01). (C) Correction network of the significant pathway clusters (listed in panel B) visualized in Cytoscape. Each cluster was made up of the the best enriched Reactome pathways within the threshold of Kappa-statistical similarity (0.3). Each node represented one enriched term and was colored by P value. In the figure, the top 2 enriched pathways and the clusters they belonged to were marked.