Mitochondria-targeted hydrogen sulfide attenuates endothelial senescence by selective induction of splicing factors <i>HNRNPD</i> and <i>SRSF2</i>

Eva Latorre; Roberta Torregrossa; Mark E. Wood; Matthew Whiteman; Lorna W. Harries

doi:doi:10.18632/aging.101500

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Research Paper Volume 10, Issue 7 pp 1666—1681

Mitochondria-targeted hydrogen sulfide attenuates endothelial senescence by selective induction of splicing factors HNRNPD and SRSF2

Figure 3. H₂S donor treatments affect splicing factor transcript expression. The change in splicing factor mRNA levels in response to 24hr treatment with H₂S donors are given ; Na-GYY4137 at 100 µg/ml, AP39, AP123, RT01 at 10 ng/ml. Green indicates up-regulated genes, red denotes down-regulated genes. The colour scale refers to fold-change in expression. Only statistically significant changes are presented in the heat map.