Research Paper Volume 10, Issue 7 pp 1682—1697

Global quantitative TPA-based proteomics of mouse brain structures reveals significant alterations in expression of proteins involved in neuronal plasticity during aging

Figure 3. Changes in protein families involved in main mechanisms of neuronal plasticity upon aging. Plots show ratios of protein concentrations in adult vs young brain structures: hippocampus (A), cerebellum (B) and cortex (C). The size of bubbles is proportional to the average protein concentration in respective young animals brain structures. Statistically significant differences are shown as the red filled circles.