Figure 13. EE effects on lifespan initiated at 18-month of age. (A) Glucose tolerance test after 3-months EE in one cohort. n=10 per group. * P<0.05, ** P<0.01. Values are means ± SEM. (B) Kaplan-Meier survival curves of combined data of 4 cohorts. n=39 for SE, n=40 for EE. Log-rank test P value shown in the figure. (C) Means of lifespan. Individual value plot of lifespan. Two-sample T test P value shown in the figure.