Research Paper Volume 10, Issue 7 pp 1758—1775

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies

Figure 1. Age estimation accuracy of the skin & blood clock in fibroblasts, keratinocytes, and microvascular endothelial cells. The left and right panels relate chronological age (x-axis) to DNAm Age estimates (y-axis) from the skin & blood clock (A,C,E,G,I) and the pan-tissue clock (Horvath 2013) (B,D,F,H,J) [6], respectively. Each row corresponds to a different tissue/cell type. DNA methylation data from fibroblasts (A,B), microvascular endothelial cells C,D), buccal epithelial cells (E,F), keratinocytes (G,H), and whole skin (dermis/epidermis) samples (I,J). Each panel reports the Pearson correlation coefficient and the error (defined as median absolute deviation between DNAm age and chronological age).