Figure 3. LMNA mutations in progeria patients. The diagram shows the structure of lamin A. It consists of globular head domain, linker regions, α-helical coiled coil domain and globular tail domain. Locations of the progeria LMNA mutations in this study were shown with molecular mechanism of mutant lamin A protein and clinical phenotype, as previously reported in  (p.Met540Thr) , (c.1824C>T) , (c.1968+1G>A) , (c.1968+2T>C), and  (c.2968G>A and c.1968+5G>A). Δ50 indicates the region of deletion in progerin, also present in ZMPSTE24 mutant progeria . Photos were reproduced with permission.