Research Paper Volume 10, Issue 10 pp 2800—2815

Epigenetic ageing is distinct from senescence-mediated ageing and is not prevented by telomerase expression

Figure 2. Effects of hTERT on growth and epigenetic ageing of adult primary human coronary artery endothelial cells. (A) Growth dynamics of primary cells from one donor (C) transduced with either empty vector (control) or hTERT expression vector (hTERT). (B) The ages of a selection of cell passages of donor C were imputed by the pan-tissue clock (left panel) or the skin & blood clock (right panel). The ages are plotted against cumulative population doubling (CPD) that corresponded to the passage of cells that were analysed.