Research Paper Volume 10, Issue 11 pp 3136—3147

Egr-1 is involved in coronary microembolization-induced myocardial injury via Bim/Beclin-1 pathway-mediated autophagy inhibition and apoptosis activation

Figure 3. Inhibition of Egr-1 reduced myocardial microinfarct areas following CME. HBFP staining stained the normal myocardium yellow, while the ischemic myocardium was stained red. The arrow indicates the microinfarct focus (x400, scale bar = 25 μm). The results are presented as the means ± SD from at least three independent experiments. *P < 0.05 compared with the CME group; #P < 0.05 compared with the CME+shRNA group.