Figure 4. Inhibition of Egr-1 decreased the myocardial AI following CME. TUNEL staining of the microinfarcted myocardium stained the apoptotic nuclei yellow-brown, while the normal nuclei were stained light blue. The arrows indicate apoptotic nuclei (x400, scale bar = 25 μm). The results are presented as the means ± SD from at least three independent experiments. aP < 0.05 compared with the Sham group; bP < 0.05 compared with the CME group; cP < 0.05 compared with the CME+shRNA group.