Research Paper Volume 10, Issue 11 pp 3136—3147

Egr-1 is involved in coronary microembolization-induced myocardial injury via Bim/Beclin-1 pathway-mediated autophagy inhibition and apoptosis activation

Figure 6. Activation of the Egr-1/Bim/Beclin-1 pathway participated in CME-induced myocardial injury. The expression of (A) the Egr-1, (B) Bim, and (C) Beclin-1 mRNAs in the myocardium of rat detected by RT-qPCR. The results are presented as the means ± SD from at least three independent experiments. aP < 0.05 compared with the Sham group; bP < 0.05 compared with the CME group; cP < 0.05 compared with the CME+shRNA group.