Research Paper Volume 10, Issue 11 pp 3136—3147

Egr-1 is involved in coronary microembolization-induced myocardial injury via Bim/Beclin-1 pathway-mediated autophagy inhibition and apoptosis activation

Figure 8. A model of the mechanism underlying the functions of the Egr-1/Bim/Beclin-1 pathway in CME-induced myocardial injury. CME triggers a complex cell death signaling pathway, including the upregulation of Egr-1, resulting in Bim activation and Beclin-1 inhibition, which inhibit myocardial autophagy and induce apoptosis to provoke myocardial injury and cardiac dysfunction. Based on the data reported in the present study, the Egr-1/Bim/Beclin-1 pathway may be involved in CME-induced myocardial injury by regulating myocardial autophagy and apoptosis.