Editorial Volume 10, Issue 11 pp 3046—3047

Cardiovascular disease, inflammation, and mRNA stability

Figure 1. Proposed working hypothesis of IL-19 reduction of inflammatory mRNA stability. Under inflammatory conditions, HuR interacts with ARE in pro-inflammatory and HuR mRNA 3’UTR and stabilizes the transcript, resulting in increased inflammatory protein abundance. When inflammation is reduced, FXR1 expression increases, with the dual outcome of increased competition with HuR for ARE occupancy, as well as reduced HuR abundance. This results in reduced transcript stability.