Research Paper Volume 10, Issue 11 pp 3294—3307

Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts

Figure 8. Azithromycin induces glycolytic activity in MRC-5 cells. After 72 hours of treatment with Azithromycin (25 to 100 µM), MRC-5 cells were subjected to metabolic flux analysis with the Seahorse XFe96, which measures ECAR (extracellular acidification rate). Note that all concentrations elevated glycolysis. n=3; ** p < 0.01,*** p < 0.001.