Research Paper Volume 10, Issue 11 pp 3294—3307

Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts

Table 1. The effects of macrolide antibiotics on BrdU-treated senescent MRC-5 fibroblasts. This table briefly summarizes the biological effects of three antibiotics, namely Erythromycin, Azithromycin and Roxithromycin, on cell viability. While Erythromycin was completely ineffective, Roxithromycin and Azithromycin selectively eliminated large numbers of senescent cells at 100 µM, but had no effect at a lower dose (50 µM). Azithromycin was found to be the most selective compound, as it eliminated senescent cells, without affecting control cells.