Research Paper Volume 10, Issue 11 pp 3397—3420

Cell cycle-dependent and -independent telomere shortening accompanies murine brain aging

Figure 4. Rate of age-dependent changes in RTL of cortical neural isolates from murine neocortex, for G0/G1 and G2/M phases of the cell cycle. A lower specific MFI ratio between aged and young specimens for G2/M-phase cells as compared to a more stable specific MFI ratio for moieties arrested at G0/G1 phase reflected a substantial age-related decline in RTL in replicative cell entities in the murine cortex over lifetime. Bars represent means ± SEM (n = 4 - 8). P-values were calculated using Student’s t-test.