Research Paper Volume 10, Issue 11 pp 3397—3420

Cell cycle-dependent and -independent telomere shortening accompanies murine brain aging

Figure 7. Telomerase activity and telomere length in the brain of aged RelaCNS-KO mice. (A) Telomerase activity, normalized against a positive HeLA cell extract, in the cortex of 18-23 months old RelaCNS-KO mice compared to age-matched RelaFlox control mice (n = 4 - 6). (B) RTL in cortical neural cells isolated from 19-20 months old RelaCNS-KO as assessed by qPCR in terms of T/S-ratios and normalized against aged-matched RelaFlox control animals (n = 3 - 4). Bars represent means ± S.E.M. P values were calculated by Student’s t-test.