Research Paper Volume 10, Issue 11 pp 3421—3437

miR-150-5p suppresses tumor progression by targeting VEGFA in colorectal cancer

Figure 3. miR-150-5p inhibited tumor growth, metastasis and angiogenesis in vivo. (A) Photographs of nude mice and xenograft tumors of CRC cells with miR-150-5p overexpression or not after 20 days of implantation. (B) Growth curves of xenografts of CRC cells with or without miR-150-5p overexpression. (C) The representative images of lungs from nude mice (left), representative CT scans of lung metastatic foci of the nude mice (middle) and the microscopic images of lung tissue sections stained by hematoxylin and eosin (right). (D) A statistical plot of the average number of lung metastases in the tail vein injection. (E) These tumor tissues were stained using anti-CD31 antibody, data are shown as the mean ±SD. n=8. ***p<0.001.