Research Paper Volume 10, Issue 11 pp 3507—3527

Angiopoietin-1 and ανβ3 integrin peptide promote the therapeutic effects of L-serine in an amyotrophic lateral sclerosis/Parkinsonism dementia complex model

Figure 1. Motor functional evaluation revealed neurological impairments as early as 2 weeks after L-BMAA injection, and the C16+Ang-1 and L-serine treatments alleviated the severity of disabilities, with the combined treatment further improving motor function. (A) Time on the rod in the rotarod test. (B) Angle at which the rats fell in the inclined plane test. (C) Average grip strength of forepaws. & p<0.05 vs. the control group, *p<0.05 vs. the C16+Ang-1 group, and #p<0.05 vs. the L-ser group.