Research Paper Volume 10, Issue 11 pp 3507—3527

Angiopoietin-1 and ανβ3 integrin peptide promote the therapeutic effects of L-serine in an amyotrophic lateral sclerosis/Parkinsonism dementia complex model

Figure 10. At 8 weeks post-injection, neurofilament disintegration and axonal destruction were found in basal ganglia of vehicle-treated group (B) in contrast with the normal control. At the same time point, intracellular movement of cytosolic TDP-43 protein (G) and high expression of hyper-phosphorylated tau (L) were detected in the striatum of the vehicle-treated group, while the C+A (C, H, M) and L-ser treatment (D, I, N) both were found to alleviate these effects in some extent, with the combined treatment (E, J, O) producing the best effects. (P, Q) Quantification of relative fluorescence of NF-200 (P) and PHF-tau (Q) staining in cells. (a) p<0.05 vs normal rats; (b) p<0.05 vs vehicle-treated rats; (c) p<0.05 vs. C16+Ang-1–treated rats; (d) p<0.05 vs. L-serine–treated rats.