Research Paper Volume 10, Issue 11 pp 3507—3527

Angiopoietin-1 and ανβ3 integrin peptide promote the therapeutic effects of L-serine in an amyotrophic lateral sclerosis/Parkinsonism dementia complex model

Figure 13. The gradual loss of neurons in the CNS of L-BMAA–treated rats was revealed by Nissl staining. However, the number of surviving neurons was markedly increased by C16+Ang-1 treatment and further still by L-serine treatment. The combined treatment produced the best effects as revealed by cell quantification.SC: spinal cord; H: hippocampi. Scale bar = 100 µm. Neurons were counted in three visual fields per section taken at 200× magnification under bright field viewing. (I-II): The rate of surviving neurons (shown as % of normal control) was calculated based on the neuron number. (a) p<0.05 vs normal rats; (b) p<0.05 vs vehicle-treated rats; (c) p<0.05 vs. C16+Ang-1–treated rats; (d) p<0.05 vs. L-serine–treated rats.