Research Paper Volume 10, Issue 11 pp 3507—3527

Angiopoietin-1 and ανβ3 integrin peptide promote the therapeutic effects of L-serine in an amyotrophic lateral sclerosis/Parkinsonism dementia complex model

Figure 3. Immunostaining of 3-NT in lumbar spinal cord sections. The clear increase in 3-NT staining in spinal cord sections from the vehicle-treated rats from 2–8 weeks post-L-BMAA injection was clearly reduced by C16+Ang1 and L-serine treatment, and the combined treatment produced the most significant effects as revealed by cell quantification (P). (Q) ROS production. The amount of ROS produced in the vehicle-treated model group was significantly greater than the levels in the other groups. C16+Ang-1 and L-serine treatments, individually, reduced the ROS level, and the combined treatment led to the lowest ROS level among all the treated groups. (a) p<0.05 vs normal rats; (b) p<0.05 vs vehicle-treated rats; (c) p<0.05 vs. C16+Ang1–treated rats; (d) p<0.05 vs. L-serine–treated rats. Scale bar = 100 μm.