Research Paper Volume 10, Issue 11 pp 3507—3527

Angiopoietin-1 and ανβ3 integrin peptide promote the therapeutic effects of L-serine in an amyotrophic lateral sclerosis/Parkinsonism dementia complex model

Figure 4. Increased expression of GSK3β in the spinal cord (A), hippocampus (B) and motor cortex (C) was observed in vehicle-treated model rats. The number of GSK3β-positive neurons was remarkably decreased by C16+Ang1 treatment and reduced to an even greater degree after L-serine treatment. The combined treatment group showed the lowest GSK3β cellular expression according to the results of cell quantification. (a) p<0.05 vs normal rats; (b) p<0.05 vs vehicle-treated rats; (c) p<0.05 vs. C16+Ang1–treated rats; (d) p<0.05 vs. L-serine–treated rats.