Research Paper Volume 10, Issue 11 pp 3507—3527

Angiopoietin-1 and ανβ3 integrin peptide promote the therapeutic effects of L-serine in an amyotrophic lateral sclerosis/Parkinsonism dementia complex model

Figure 7. Immunostaining for APP in sections of the hippocampus. The clear increase in APP staining in the vehicle-treated model rats from 2–8 weeks after L-BMAA injection was obviously reduced by C16+Ang-1 and L-serine treatment individually, and the combined treatment with both led to the most significant effect as revealed by cell quantification. (a) P<0.05 vs normal rats; (b) p<0.05 vs vehicle-treated rats; (c) p<0.05 vs. C16+Ang-1–treated rats;(d) p<0.05 vs. L-serine–treated rats. Scale bar = 100 μm.