**Figure 4.** **Meta analysis forest plots for predicting time-to-coronary heart disease.** Each panel reports a meta-analysis forest plot for combining hazard ratios predicting time to CHD and the DNAm-based biomarker (reported in the figure heading) across different strata formed by racial groups within cohorts. (**A**) Results for AgeAccelGrim. Each row reports a hazard ratio (for time-to-CHD) and a 95% confidence interval resulting from a Cox regression model in each of 9 strata (defined by cohort and racial groups). Results for (age adjusted) DNAm-based surrogate markers of (**B**) adrenomedullin (ADM), (**C**) beta-2 microglobulin (B2M), (**D**) cystatin C (Cystatin C), (**E**) growth differentiation factor 15 (GDF-15), (**F**) leptin, (**G**) plasminogen activation inhibitor 1 (PAI-1), (**H**) tissue inhibitor metalloproteinase 1 (TIMP-1) and (**I**) smoking pack-years (PACKYRS). The sub-title of each panel reports the meta-analysis p-value and a p-value for a test of heterogeneity Cochran Q test (Het.). (**A**) Each hazard ratio (HR) corresponds to a one-year increase in AgeAccelGrim. (**B**-**H**) Each hazard ratio corresponds to an increase in one-standard deviation. (**I**) Hazard ratios correspond to a one unit increased in DNAm pack-years. The most significant meta-analysis P value (here AgeAccelGrim) is marked in red.