Online ISSN: 1945-4589

Volume 11, Issue 2

31 January, 2019
pp 285—836

About the Cover

The cover features Figure 1 "Flowchart for developing DNAm GrimAge" from Lu et al.

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Table of Contents

Editorials

MSC - targets for atherosclerosis therapy

Ines Colmegna, Ursula Stochaj,
https://doi.org/10.18632/aging.101735 pp 285—286
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A call for action in bleeding prevention

Felice Gragnano, Negar Manavifar, Marco Valgimigli,
https://doi.org/10.18632/aging.101745 pp 287—288
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The gut microbiome of healthy long-living people

Feilong Deng, Ying Li, Jiangchao Zhao,
https://doi.org/10.18632/aging.101771 pp 289—290
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Hormone therapy outcome in lymphedema

Barbara Garmy-Susini,
https://doi.org/10.18632/aging.101772 pp 291—292
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HDL dysfunction, function, and heart failure

Mudit Mishra, Ilayaraja Muthuramu, Bart De Geest,
https://doi.org/10.18632/aging.101775 pp 293—294
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Aging, cardiotoxicity, and chemotherapy

Edimar Alcides Bocchi, Mônica Samuel Avila, Silvia Moreira Ayub-Ferreira,
https://doi.org/10.18632/aging.101776 pp 295—296
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Septal hypertrophy and cell cycle re-entry in AD

Tracy Butler, Richard Bowen, Craig S. Atwood,
https://doi.org/10.18632/aging.101777 pp 297—298
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Endothelial stiffening in dyslipidemia

Elizabeth Le Master, Irena Levitan,
https://doi.org/10.18632/aging.101778 pp 299—300
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Mitohormesis and autophagic balance in Parkinson disease

Diana Luz Juarez-Flores, Ingrid Gonzalez-Casacuberta, Gloria Garrabou,
https://doi.org/10.18632/aging.101779 pp 301—302
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Research Papers

DNA methylation GrimAge strongly predicts lifespan and healthspan

Ake T. Lu, Austin Quach, James G. Wilson, Alex P. Reiner, Abraham Aviv, Kenneth Raj, Lifang Hou, Andrea A. Baccarelli, Yun Li, James D. Stewart, Eric A. Whitsel, Themistocles L. Assimes, Luigi Ferrucci, Steve Horvath,
https://doi.org/10.18632/aging.101684 pp 303—327
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Impairment of hypoxia-induced angiogenesis by LDL involves a HIF-centered signaling network linking inflammatory TNFα and angiogenic VEGF

Fengyan Jin, Xiangyu Zheng, Yanping Yang, Gang Yao, Long Ye, Thorsten R. Doeppner, Dirk M. Hermann, Haifeng Wang, Yun Dai,
https://doi.org/10.18632/aging.101726 pp 328—349
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BCL2L10/BECN1 modulates hepatoma cells autophagy by regulating PI3K/AKT signaling pathway

Jiafa He, Li Deng, Heping Liu, Taiying Chen, Shengying Chen, Shangzhou Xia, Yubin Liu,
https://doi.org/10.18632/aging.101737 pp 350—370
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Age-related alterations in the modulation of intracortical inhibition during stopping of actions

Lize Hermans, Celine Maes, Lisa Pauwels, Koen Cuypers, Kirstin-Friederike Heise, Stephan P. Swinnen, Inge Leunissen,
https://doi.org/10.18632/aging.101741 pp 371—385
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Loss of GPR109A/HCAR2 induces aging-associated hepatic steatosis

Ravirajsinh N. Jadeja, Malita A. Jones, Ollya Fromal, Folami L. Powell, Sandeep Khurana, Nagendra Singh, Pamela M. Martin,
https://doi.org/10.18632/aging.101743 pp 386—400
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3,4,5-Tricaffeoylquinic acid induces adult neurogenesis and improves deficit of learning and memory in aging model senescence-accelerated prone 8 mice

Kazunori Sasaki, Julie Davies, Noelia Geribaldi Doldán, Sayo Arao, Farhana Ferdousi, Francis G. Szele, Hiroko Isoda,
https://doi.org/10.18632/aging.101748 pp 401—422
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Expression and gene regulation network of RBM8A in hepatocellular carcinoma based on data mining

Yan Lin, Rong Liang, Yufen Qiu, Yufeng Lv, Jinyan Zhang, Gang Qin, Chunling Yuan, Zhihui Liu, Yongqiang Li, Donghua Zou, Yingwei Mao,
https://doi.org/10.18632/aging.101749 pp 423—447
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miRNA-mRNA crosstalk in myocardial ischemia induced by calcified aortic valve stenosis

Chenyang Duan, Zhezhe Cao, Fuqin Tang, Zhao Jian, Chunshui Liang, Hong Liu, Yingbin Xiao, Liangming Liu, Ruiyan Ma,
https://doi.org/10.18632/aging.101751 pp 448—466
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Combined eight-long noncoding RNA signature: a new risk score predicting prognosis in elderly non-small cell lung cancer patients

Runchen Miao, Cuiyun Ge, Xing Zhang, Yang He, Xiaohua Ma, Xiaohong Xiang, Jingxian Gu, Yunong Fu, Kai Qu, Chang Liu, Qifei Wu, Ting Lin,
https://doi.org/10.18632/aging.101752 pp 467—479
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Development of a prognostic index based on an immunogenomic landscape analysis of papillary thyroid cancer

Peng Lin, Yi-nan Guo, Lin Shi, Xiao-jiao Li, Hong Yang, Yun He, Qing Li, Yi-wu Dang, Kang-lai Wei, Gang Chen,
https://doi.org/10.18632/aging.101754 pp 480—500
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Prognostic value of immune checkpoint molecules in head and neck cancer: a meta-analysis

Yi-Qun Jia, Bo Yang, Li-Ling Wen, Wen-Xin Mu, Zhi Wang, Bin Cheng,
https://doi.org/10.18632/aging.101756 pp 501—522
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lncRNA-ES3/miR-34c-5p/BMF axis is involved in regulating high-glucose-induced calcification/senescence of VSMCs

Xiao Lin, Jun-Kun Zhan, Jia-Yu Zhong, Yan-Jiao Wang, Yi Wang, Shuang Li, Jie-Yu He, Pan Tan, Yi-Yin Chen, Xue-Bin Liu, Xing-Jun Cui, You-Shuo Liu,
https://doi.org/10.18632/aging.101758 pp 523—535
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Geniposide-mediated protection against amyloid deposition and behavioral impairment correlates with downregulation of mTOR signaling and enhanced autophagy in a mouse model of Alzheimer's disease

Zhihua Zhang, Xiaojian Wang, Di Zhang, Yueze Liu, Lin Li,
https://doi.org/10.18632/aging.101759 pp 536—548
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S100A13 promotes senescence-associated secretory phenotype and cellular senescence via modulation of non-classical secretion of IL-1α

Yuanyuan Su, Chenzhong Xu, Zhaomeng Sun, Yao Liang, Guodong Li, Tanjun Tong, Jun Chen,
https://doi.org/10.18632/aging.101760 pp 549—572
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Anti-senescence role of heterozygous fumarate hydratase gene knockout in rat lung fibroblasts in vitro

Zhirui Fan, Lifeng Li, Xiaoli Li, Meng Zhang, Mengmeng Dou, Jing Zhao, Jing Cao, Xiaoming Deng, Mingzhi Zhang, Huixiang Li, Zhenhe Suo,
https://doi.org/10.18632/aging.101761 pp 573—589
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Relationship between senescence in macaques and bone marrow mesenchymal stem cells and the molecular mechanism

Xing-hua Pan, Yu-hao Chen, Yu-kun Yang, Xue-juan Zhang, Qing-keng Lin, Zi-an Li, Xue-min Cai, Rong-qing Pang, Xiang-qing Zhu, Guang-ping Ruan,
https://doi.org/10.18632/aging.101762 pp 590—614
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MiR-223-3p promotes cell proliferation and metastasis by downregulating SLC4A4 in clear cell renal cell carcinoma

Wen Xiao, Xuegang Wang, Tao Wang, Jinchun Xing,
https://doi.org/10.18632/aging.101763 pp 615—633
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Efficacy of remote ischemic conditioning on improving WMHs and cognition in very elderly patients with intracranial atherosclerotic stenosis

Da Zhou, Jiayue Ding, Jingyuan Ya, Liqun Pan, Chaobo Bai, Jingwei Guan, Zhongao Wang, Kexin Jin, Qi Yang, Xunming Ji, Ran Meng,
https://doi.org/10.18632/aging.101764 pp 634—648
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A novel six-microRNA-based model to improve prognosis prediction of breast cancer

Jianguo Lai, Hongli Wang, Zihao Pan, Fengxi Su,
https://doi.org/10.18632/aging.101767 pp 649—662
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Association between height and circulating CD34-positive cells taken into account for the influence of enhanced production among elderly Japanese men: a cross-sectional study

Yuji Shimizu, Hirotomo Yamanashi, Yuko Noguchi, Jun Koyamatsu, Mako Nagayoshi, Kairi Kiyoura, Shoichi Fukui, Mami Tamai, Shin-Ya Kawashiri, Kazuhiko Arima, Takahiro Maeda,
https://doi.org/10.18632/aging.101768 pp 663—672
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IDH mutation-specific radiomic signature in lower-grade gliomas

Xing Liu, Yiming Li, Shaowu Li, Xing Fan, Zhiyan Sun, Zhengyi Yang, Kai Wang, Zhong Zhang, Tao Jiang, Yong Liu, Lei Wang, Yinyan Wang,
https://doi.org/10.18632/aging.101769 pp 673—696
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Chronic hyperglycemia regulates microglia polarization through ERK5

Congde Chen, Suichun Wu, Zipu Hong, Xiaoming Chen, Xiaoou Shan, Shane Fischbach, Xiangwei Xiao,
https://doi.org/10.18632/aging.101770 pp 697—706
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Age-related immune-modulating properties of seminal fluid that control the severity of asthma are gender specific

Yuichi Niikura, Takashi Ishii, Jurika Murakami, Tomoya Narita, Yoko Fujita, Hiroaki Negishi, Yuji Taketani, Naomi Yamashita,
https://doi.org/10.18632/aging.101773 pp 707—723
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CD56-negative NK cells with impaired effector function expand in CMV and EBV co-infected healthy donors with age

Bojana Müller-Durovic, Jasmin Grählert, Oliver P. Devine, Arne N. Akbar, Christoph Hess,
https://doi.org/10.18632/aging.101774 pp 724—740
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Association between antidiabetic agents use and leukocyte telomere shortening rates in patients with type 2 diabetes

Juanhong Liu, Yuanlong Ge, Shu Wu, Delin Ma, Weijie Xu, Ye Zhang, Yan Yang,
https://doi.org/10.18632/aging.101781 pp 741—755
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Lactobacillus paracasei PS23 decelerated age-related muscle loss by ensuring mitochondrial function in SAMP8 mice

Li-Han Chen, Shih-Yi Huang, Kuo-Chin Huang, Chih-Chieh Hsu, Kuen-Cheh Yang, Lin-Ai Li, Ching-Hung Chan, Hui-Yu Huang,
https://doi.org/10.18632/aging.101782 pp 756—770
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The curcumin analog EF24 is a novel senolytic agent

Wen Li, Yonghan He, Rongping Zhang, Guangrong Zheng, Daohong Zhou,
https://doi.org/10.18632/aging.101787 pp 771—782
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Book Review

Superb book about Alzheimer’s disease

Iver Mysterud,
https://doi.org/10.18632/aging.101801 pp 783—786
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Reviews

Impact of Apolipoprotein E gene polymorphism during normal and pathological conditions of the brain across the lifespan

Diego Iacono, Gloria C. Feltis,
https://doi.org/10.18632/aging.101757 pp 787—816
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Can ovarian aging be delayed by pharmacological strategies?

Jinjin Zhang, Qian Chen, Dingfu Du, Tong Wu, Jingyi Wen, Meng Wu, Yan Zhang, Wei Yan, Su Zhou, Yan Li, Yan Jin, Aiyue Luo, Shixuan Wang,
https://doi.org/10.18632/aging.101784 pp 817—832
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Letter to the Editor

The epigenetic clock: a molecular crystal ball for human aging?

Simone Ecker, Stephan Beck,
https://doi.org/10.18632/aging.101712 pp 833—835
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Correction

Correction: A functional variant of SMAD4 enhances macrophage recruitment and inflammatory response via TGF-β signal activation in Thoracic aortic aneurysm and dissection

Ying Wang, Pei Yin, Yi-Huan Chen, Yun-Sheng Yu, Wen-Xue Ye, Hao-Yue Huang, Zhen-Chun Ji, Zhen-Ya Shen,
https://doi.org/10.18632/aging.101812 pp 836
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