Research Paper Volume 11, Issue 2 pp 303—327

DNA methylation GrimAge strongly predicts lifespan and healthspan

Figure 6. Cross sectional correlations between DNAm biomarkers and lifestyle factors. Robust correlation coefficients (biweight midcorrelation [62]) between 1) AgeAccelGrim and its eight age-adjusted underlying DNAm-based surrogate biomarkers and 2) 38 variables including self-reported diet, 9 dietary biomarkers, 12 variables related to metabolic traits and central adiposity, and 5 life style factors. The 2-color scale (blue to red) color-codes bicor correlation coefficients in the range [-1, 1]. The green color scale (light to dark) applied to unadjusted P values. The analysis was performed on the WHI cohort in up to 4200 postmenopausal women. An analogous analysis stratified by race/ethnicity can be found in Supplementary Fig. 30.