Editorial Volume 11, Issue 1 pp 5—6

ER stress links aging to sporadic ALS

Figure 1. Schematic representation of feed-forward cycle of SOD1WT aggregation and ER stress occurring during aging. ER stress triggers accumulation of disulfide-crosslinked SOD1WT aggregates in the ER of high molecular weight, which further induce ER stress contributing to sALS pathology.