Research Paper Volume 10, Issue 12 pp 4141—4151

Naringin targets Zeb1 to suppress osteosarcoma cell proliferation and metastasis

Figure 5. Naringin inhibits lung invasion by MG63 cells in vivo. (A) Representative images of lung histopathology (H&E staining; 400×) from mice injected with MG63 cells and treated daily with two different doses of naringin or NaCl (control) for 16 days. (B, C) Zeb1, Cyclin D1, bcl-2, and MMP2 expression in liver tumor samples, detected by Western blot (B) and real-time PCR (C). **P < 0.05, compared with NaCl-treated controls.