Research Paper Volume 11, Issue 1 pp 174—184

Loss of the interaction between estradiol and insulin-like growth factor I in brain endothelial cells associates to changes in mood homeostasis during peri-menopause in mice

Figure 2. Effects of exercise on IGF-I in middle-aged females. (A) Hippocampal levels of IGF-I did not change after exercise in middle-aged female mice (n=9-10). (B) Serum IGF-I increased in middle-aged females after exercise (n= 6-7). **p<0.01 and ***p<0.001 vs respective control in this and following figures.