Research Paper Volume 11, Issue 1 pp 174—184

Loss of the interaction between estradiol and insulin-like growth factor I in brain endothelial cells associates to changes in mood homeostasis during peri-menopause in mice

Figure 3. Effects of exercise on clusterin and its receptor in middle-aged females. (A) Hippocampal levels of clusterin (Clu) changed in an age-dependent manner in response to exercise (n=5-10, p<0.05). (B) Hippocampal levels of the Clu receptor Plxna4 did not change with age, nor with exercise (n=7-12). *p<0.05 vs respective control in this and following figures.