Research Paper Volume 11, Issue 1 pp 209—229

Oxidative stress induces club cell proliferation and pulmonary fibrosis in Atp8b1 mutant mice

Figure 9. IPF lungs show aberrant CCSP expression at bronchiolar epithelium with hypercellularity. Immunohistochemical staining for CCSP was performed on lung tissue sections from patients with IPF and patients with COPD (control for IPF) (n=4 for each). Labeled boxes correspond to their respective enlarged images. (A, B, C & D) Representative photomicrographs of lung sections from COPD patients display relatively organized arrangement of CCSP expression in apical side of bronchiolar epithelium. (E, F, G & H) Representative photomicrographs of lung sections from IPF patients. Hyperplastic bronchiolar epithelium randomly displays accumulation of cells with varying degrees of CCSP expression. Magnifications: (A, C, E, G) 40X; (H) 100x; (B, D, F) 200X. Data presented are representative of one experiments.