Research Paper Volume 11, Issue 2 pp 386—400

Loss of GPR109A/HCAR2 induces aging-associated hepatic steatosis

Figure 4. Increased lipogenesis and decreased lipolysis accounts for hepatocyte fat accumulation in Gpr109a-/- mice. (A-F) mRNA expression of genes regulating hepatocyte lipid metabolism was performed by qPCR assay. Data are presented as mean ± S.E.M for (n=4). *p<0.05 vs. WT. SREBP1c; sterol regulatory element-binding transcription factor 1, FAS; fatty acid synthase, ACC; acetyl-CoA carboxylase, PPARα; peroxisome proliferator-activated receptor alpha, ACOX-1; Acyl-CoA Oxidase 1, CPT1A; Carnitine palmitoyltransferase IA.