Research Paper Volume 11, Issue 2 pp 386—400

Loss of GPR109A/HCAR2 induces aging-associated hepatic steatosis

Figure 5. Age-associated adipocyte hypertrophy is a feature of Gpr109a-/- mice. (A-D) 12-month-old Gpr109a-/- mice had more visceral fat accumulation compared to age-matched WT mice. (E) Representative images (20X magnification) of hematoxylin and eosin-staining and (F-G) histo-morphometric evaluations performed using cross-sections of epididymal fat pads isolated from 12-month old WT and Gpr109a-/- mice. Data is represented as mean ± S.E.M for (n=4). *p<0.05 vs. WT.