Research Paper Volume 11, Issue 2 pp 386—400

Loss of GPR109A/HCAR2 induces aging-associated hepatic steatosis

Figure 6. Age-associated fat accumulates in Gpr109a-/- mice via increased lipogenesis. (A-G) mRNA expression of genes regulating hepatocyte lipid metabolism was performed by qPCR assay. Data is represented as mean ± S.E.M for (n=4). *p<0.05 vs. WT. PPAR-γ; peroxisome proliferator-activated receptor gamma, CEBPα; CCAAT/enhancer-binding protein alpha, ACC; acetyl-CoA carboxylase, SCD-1; stearoyl-CoA desaturase-1, ATGL; adipose triglyceride lipase, HSL; hormone-sensitive lipase, ACOX-1; Acyl-CoA Oxidase 1.