Research Paper Volume 11, Issue 2 pp 401—422

3,4,5-Tricaffeoylquinic acid induces adult neurogenesis and improves deficit of learning and memory in aging model senescence-accelerated prone 8 mice

Figure 2. Effect of oral administration of 3,4,5-triCaffeoylquinic acid (TCQA) on anterior (A–C) and posterior (D–F) DG stem cell activation and neurogenesis. SAMP8 mice were administrated with TCQA (5 mg/kg) for 30 days. Photomicrographs show adult mouse brain in coronal sections containing the anterior (A) and posterior (D) DG processed for immunohistochemical detection of proliferating BrdU+ cells (red) and GFAP, a protein expressed by stem cells in the DG (green). Graphs represents the number of BrdU+ cells that co-express GFAP in anterior (B) and posterior (E) DG. Graphs represent the number of BrdU+ cells that co-express the mature neuronal marker NeuN in the anterior (E) and posterior (F) DG. Each bar represents the mean ±SEM * p < 0.05, ** p < 0.01 vs. SAMP8+TCQA group.