Research Paper Volume 11, Issue 2 pp 401—422

3,4,5-Tricaffeoylquinic acid induces adult neurogenesis and improves deficit of learning and memory in aging model senescence-accelerated prone 8 mice

Figure 3. Effect of oral administration of 3,4,5-tricaffeoylquinic acid (TCQA) on subventricular zone (SVZ) proliferation. SAMP8 mice were administrated with TCQA (5 mg/kg) for 30 days (A) Photomicrograph shows adult mouse brain coronal sections containing the SVZ processed for immunohistochemical detection of proliferating BrdU+ cells (red) and GFAP+ (green), an astrocyte marker found in SVZ NSC. (B, C) Graphs represent the number of BrdU+/GFAP+ and BrdU+ cells, respectively in the different treatment groups.