Research Paper Volume 11, Issue 2 pp 536—548

Geniposide-mediated protection against amyloid deposition and behavioral impairment correlates with downregulation of mTOR signaling and enhanced autophagy in a mouse model of Alzheimer's disease

Figure 2. Geniposide improves NOR scores in APP/PS1 mice. (A) Schematic diagram of the NOR test. (B) NOR test results. The DI of APP/PS1 mice was significantly decreased compared to WT, and was improved by geniposide treatment. Data are mean ± SEM (n = 13–15). ***p < 0.001 vs. WT; #p < 0.05 vs. APP/PS1. (one-way ANOVA, Tukey's Multiple Comparison Test). WT: wild-type mice. GP: geniposide.