Research Paper Volume 11, Issue 2 pp 536—548

Geniposide-mediated protection against amyloid deposition and behavioral impairment correlates with downregulation of mTOR signaling and enhanced autophagy in a mouse model of Alzheimer's disease

Figure 4. Geniposide ameliorates neuropathological changes in APP/PS1 mice. Sections obtained from the hippocampus (A) and cortex (B) were stained with HE. Neurons in WT mice were normal in shape and orderly arranged. In APP/PS1 mice, neurons were lost and darkly stained. Shrinkage and necrosis were observed in scattered neurons (yellow arrow). Geniposide treatment reduced these pathological changes. A) A-C, 4× magnification; D-F, 20× magnification; B) A-C, 2× magnification; D-F, 40× magnification).