Research Paper Volume 11, Issue 2 pp 536—548

Geniposide-mediated protection against amyloid deposition and behavioral impairment correlates with downregulation of mTOR signaling and enhanced autophagy in a mouse model of Alzheimer's disease

Figure 5. Geniposide attenuates Aβ1-40 plaque formation in the hippocampi of APP/PS1 mice. (A) Representative images of Aβ1-40-stained brain sections (A-C: 4× magnification; D-F: 10× magnification). (B) Percentage of the area occupied by Aβ 1-40 plaques. (C) Quantification of Aβ plaque density. Data are presented as mean ± SEM (n = 6). ##p < 0.01, ###p < 0.001 (one-way ANOVA, Tukey's Multiple Comparison Test). WT: wild-type mice. GP: geniposide.