Research Paper Volume 11, Issue 2 pp 536—548

Geniposide-mediated protection against amyloid deposition and behavioral impairment correlates with downregulation of mTOR signaling and enhanced autophagy in a mouse model of Alzheimer's disease

Figure 6. Geniposide reduces soluble Aβ1-40 and Aβ1-42 levels in hippocampi of APP/PS1 mice. Soluble Aβ1-40 (A) and Aβ1-42 (B) levels were measured by ELISA in the hippocampi of WT and APP/PS1 mice. In the latter, geniposide treatment lowered the expression of both Aβ alloforms. Data are presented as mean ± SEM (n = 6). #p < 0.05 (one-way ANOVA, Tukey's Multiple Comparison Test). WT: wild-type mice. GP: geniposide.