Research Paper Volume 11, Issue 2 pp 536—548

Geniposide-mediated protection against amyloid deposition and behavioral impairment correlates with downregulation of mTOR signaling and enhanced autophagy in a mouse model of Alzheimer's disease

Figure 7. Geniposide upregulates the expression of autophagy markers in the hippocampi of APP/PS1 mice. (A) Representative images of LC3-II-stained brain sections and quantification of LC3-II-positive neurons; (B) Representative images of Beclin1-stained brain sections and quantification of Beclin1-positive neurons. Numbers of both LC3-II and Beclin1 positive neurons in APP/PS1 mice were reduced compared to WT, and geniposide reversed those reductions. (A-C, 4× magnification; D-F, 40× magnification). Data are presented as mean ± SEM (n = 6). *** p < 0.001, APP/PS1 mice vs. WT; ### p < 0.001, geniposide-treated vs. untreated APP/PS1 mice (one-way ANOVA, Tukey's Multiple Comparison Test). WT: wild-type mice. GP: geniposide.