Research Paper Volume 11, Issue 2 pp 615—633

MiR-223-3p promotes cell proliferation and metastasis by downregulating SLC4A4 in clear cell renal cell carcinoma


Figure 1. MiR-223-3p expression is upregulated in ccRCC and predicts a poor prognosis. MiR-223-3p levels in 71 normal tissues and 506 ccRCC tissues were downloaded from the dataset of TCGA-KIRC. The levels of miR-223-3p were compared according to different clinicopathological parameters: (A) cancer versus para-cancer, and cancer versus paired para-cancer. (B) The ROC curve displays that miR-223-3p could effectively distinguish ccRCC from para-cancer and paired para-cancer tissues, with AUCs of 0.7609, CI 95% (0.6964 to 0.8254) (p < 0.0001) and 0.7337, CI 95% (0.6494 to 0.8180) (p < 0.0001), respectively. (CI) MiR-223-3p expression was analyzed in ccRCC patients according to (C) lymph node metastasis, (D) distant metastasis, (E) T stage, (F) TNM stage, (G) grade, (H) OS and (I) DFS. Data are shown as the mean ± SEM. * p < 0.05; ** p < 0.01; *** p < 0.001; ### p < 0.001.