Figure 5. Age-related functional alteration of seminal fluid in pathogenesis of adult asthma. Factor A in young adult males exerts anti-inflammatory activity and may contribute to a low basal immune response compared with that in young adult females (Figure 1C and Figure 3B–D). In contrast, Factor B presents in sexually mature males and seems to exert pro-inflammatory activity (Figure 3D and Figure 4D). Both Factors A and B exhibit anti-inflammatory functions in young adult asthmatic female mice (Figure 1C). The presence of these two factors is likely associated with the gender bias and age-related progression of adult asthma.