**Figure 1.** **Comparison of telomere length and TSR between treated vs untreated T2DM patients.** Linear regression analysis of telomere length and age in the treatment group (**A**) and nontreatment group (**B**); comparison of telomere length (**C**) and TSR (**D**) between the two groups. Solid lines in **A** and **B** indicate mean telomere lengths, calculated by regression analyses; y = -14.01*x+6976 in **A** (*r* = -0.24, *P* < 0.0001) and y = -15.74*x+7141 in **B** (*r* = -0.27, *P* < 0.05). y = telomere length in bp and x = age in years. (**D**) TSR was found to be -14.01 ± 3.28 bp/year in the treatment group (n = 304) and -15.74 ± 6.21 bp/year in the nontreatment group (n = 84). Telomere length is presented as the mean ± SD. TSRs are presented as the mean ± SEM. ns indicates *P* > 0.05, ***indicates *P* < 0.001