Research Paper Volume 11, Issue 3 pp 874—884

MAPT rs242557 variant is associated with hippocampus tau uptake on 18F-AV-1451 PET in non-demented elders

Figure 3. Quantitative comparisons for adjusted correlations of hippocampus tau PET SUVR levels with rs242557 variant in the subgroups categorized by APOE ε4 carriage. (A) Left hippocampus tau PET SUVR for each subject in the APOE ε4 non-carriers is plotted separated by rs242557 genotype (adjusted β = 0.140, p < 0.001, Bonferroni corrected p = 0.006). (B) Right hippocampus tau PET SUVR for each subject in the APOE ε4 non-carriers is plotted separated by rs242557 genotype (adjusted β = 0.134, p < 0.001, Bonferroni corrected p = 0.004). (C) Left hippocampus tau PET SUVR for each subject in the APOE ε4 carriers is plotted separated by rs242557 genotype (adjusted β = 0.040, p = 0.536). (D) Right hippocampus tau PET SUVR for each subject in the APOE ε4 carriers is plotted separated by rs242557 genotype (adjusted β = 0.035, p = 0.616).