Research Paper Volume 11, Issue 2 pp 771—782

The curcumin analog EF24 is a novel senolytic agent

Figure 1. Senolytic activities of different curcumin analogs. (A-D) Chemical structures of EF24 (A), HO-3687 (B), 2-HBA (C) and dimethoxycurcumin (DIMC) (D). (E-H) Effect of EF24 (E), HO-3687 (F), 2-HBA (G) and DIMC (H) on the viability of WI-38 non-senescent cells (NCs) and IR‐induced senescent cells (IR-SCs) after the cells were treated by indicated concentrations of compounds for 72 h. Data are represented as mean ± SEM of three independent assays.