Research Paper Volume 11, Issue 2 pp 771—782

The curcumin analog EF24 is a novel senolytic agent

Figure 6. EF24 synergistically kills SCs with ABT263. (A) WI‐38 IR‐induced senescent cells (IR-SCs) were treated with indicated concentrations of EF24 in the absence or presence of 1.25 µM ABT263 for 72 h. (B) IR-SCs were treated with indicated concentrations of ABT263 in the absence or presence of 2.5 µM EF24 for 72 h. Cell viability was assayed by flow cytometer after PI staining. Data are represented as mean ± SEM of three independent experiments. (C) Coefficient of drug interaction (CDI) values were calculated for the combination treatment of 2.5 µM EF24 with indicated concentrations of ABT263.