Editorial Volume 11, Issue 3 pp 839—840

CnAβ1 shifts cardiac metabolism

Figure1. CnAβ1 alternative signalling promotes activation of the mTORC2/Akt pathway. (A) CnAβ1 is the result of an alternative polyadenylation of Exon 12 in the CnAβ gene. (B) CnAβ1’s alternative C-terminal region includes an LXVP motif and a Golgi localization sequence. (C) CnAβ1 is localized in the Golgi apparatus through its interaction with Cog8 and modulates mTORC2 phosphorylation of Akt. (D) The LXVP inhibitory motif blocks CnAβ1’s catalytic domain even in the presence of Ca2+ and calmodulin. The schematic is based on [3].